Ototoxicity of Aminoglycosides the Modern Concepts

Aminoglycosides are broad-spectrum antibacterial agents used in the treatment of urinary tract infections, tuberculosis, visceral leishmaniasis, sepsis newborns, as well cystic fibrosis. However, use aminoglycosides is limited due to their ototoxicity — risk developing serious adverse reactions, particular, persistent irreversible hearing loss and vestibular disorders associated with death hair cells inner ear. The review analyzes scientific data on possible mechanisms aminoglycosides’ damaging effect Genetically determined causes contributing manifestation ototoxic properties drugs this group described. necessity genetic screening for carriage mutations m.1555A>G m.1494C>T MT-RNR1 gene mitochondrial DNA substantiated order minimize patients hereditary predisposition. Understanding will make it find ways prevent correct after use.